Bms 247550-1
Ixabepilone
CAS: 219989-84-1
Molecular Formula: C27H42N2O5S
Bms 247550-1 - Names and Identifiers
| Name | Ixabepilone |
| Synonyms | Ixempra IXABEPILONE Ixabepilone Ixempra kit Bms 247550-1 Unii-K27005np0a Azi-epothilone B Aza-epothilone B (1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-1,5,7,9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione |
| CAS | 219989-84-1 |
| EINECS | 630-424-7 |
| InChI | InChI=1/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1 |
Bms 247550-1 - Physico-chemical Properties
| Molecular Formula | C27H42N2O5S |
| Molar Mass | 506.7 |
| Density | 1.122±0.06 g/cm3(Predicted) |
| Melting Point | >160°C (dec.) |
| Boling Point | 697.8±55.0 °C(Predicted) |
| Specific Rotation(α) | D22 -40.7° (c = 1.0 in chloroform) |
| Flash Point | 375.8°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.93E-20mmHg at 25°C |
| Appearance | White solid. |
| Color | White to Off-White |
| pKa | 13.73±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.532 |
| Use | Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer. |
| In vitro study | BMS-247550 is a highly potent cytotoxic agent capable of killing cancer cells at low concentrations and still has its antitumor activity in human paclitaxel-resistant or paclitaxel-insensitive cancers. |
| In vivo study | In in vivo experiments, the antitumor activity of BMS-247550 was better than that of paclitaxel in both paclitaxel-resistant and paclitaxel-sensitive tumors. In the study, BMS-247550 was more effective than paclitaxel in all five paclitaxel-resistant tumors. For three paclitaxel-sensitive human tumor xenograft models, BMS-247550 was as effective as paclitaxel. |
Bms 247550-1 - Risk and Safety
| HS Code | 2941906000 |
Bms 247550-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.974 ml | 9.868 ml | 19.736 ml |
| 5 mM | 0.395 ml | 1.974 ml | 3.947 ml |
| 10 mM | 0.197 ml | 0.987 ml | 1.974 ml |
| 5 mM | 0.039 ml | 0.197 ml | 0.395 ml |
Last Update：2024-01-02 23:10:35
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